At Pondera® we are committed to the evaluation and testing (Endorphinate® Science) of each of our products.  Our first clinical study Endorphinate® Case Study Summary (203 subjects) was completed in 2011.  In 2013, we posted an anonymous survey on line that was completed by 300 customers.   On line Anonymous Survey Results (300 Respondents).  Our  ongoing clinical research supplements the original study as we develop and expand our product line.  The following information is provided to assist your evaluation of Endorphinate®‘s mechanism of action, safety and efficacy: 

  •  How Does Endorphinate Work?  How Does Endorphinate Work FAQ
  • What about the “testimonials”?  Each of the testimonials is an exact “cut and paste” copy of the answer by a customer to the survey question: “Please use the space below to tell us more about your Endorphinate® experience.”  The are unscripted, unprompted and unedited.
  • How do you get answers to specific clinical questions? Our Clinical Division Director, Dr. Steven Crain, a clinical psychologist, has been extensively involved in the development and use of our products.  Please contact Dr. Crain with your clinical questions by e-mail at or telephone: (814) 769-1980.
  • Pondera Endorphinate Patent.  (US Patent No. 8,372,414;  February 12, 2013) A method to safely and effectively treat Anxiety conditions, symptoms and/or disorders in a subject in need comprising: (a) administering at least one Receptor Switcher to the subject, wherein the receptor switcher is N-acetyl cysteine; and (b) administering at least one Endorphin Enhancer to the subject, wherein the endorphin enhancer is a compound comprising caffeine.

Wholesale purchasers:  

Please contact William Crain, President and Director of Customer Services and Marketing (  with your contact information and as much information as possible regarding the number of units you are considering for your first order and an estimate regarding frequency and size of orders for the following 4 quarters.  Mr. Crain will then provide you with a customer-specific wholesale price that will be locked in for at least 12 month after the first order.