Endorphinate® is the only available safe and natural way to enhance and balance endorphins, critical to the restoration and maintenance of healthy physical and emotional stress responses.

Endorphinate® PR

  • What are the benefits? Endorphinate® PR helps promote
    • A reduction in inflammation and minor pain unassociated with any disease state, i.e. muscle pain following exercise.
    • Relief from tension, anxiety, anger, and cravings.
    • Reduced physical and emotional distress due to endorphin imbalances & inflammation.
    • Enhanced adaptive response to many types of stress.
    • Increased comfort, calm, energy, positive mood, concentration, and well-being.
    • Improved emotional, interpersonal and mental functioning.
    • Greater self-control over feelings, thoughts, behaviors, and substance use.
    • How quickly will you experience the benefits of Endorphinate®?
      • Some individuals report benefits within minutes, hours, and days of initial dosing.
      • Others find that their benefits are experienced more slowly over the first few weeks.
      • Major benefits typically continue to increase over months of daily use.
      • How much Endorphinate® PR should you take?  Although many people receive the benefits they require from two capsules daily, some find that they prefer three capsules daily. Most people start with one capsule, twice daily, and many then increase to three caps/day. Before taking two cap twice daily or three caps twice daily, please consult your health care professional.
      •  Energizing effects.  Endorphinate® PR stimulates endorphin production, which promotes mental energy and alertness as well as serenity and well-being.  For those sensitive to caffeine, we suggest taking the initial daily dose upon awakening and the last dose by mid-afternoon, or consider using caffeine-free Endorphinate® CF.
      • Restful sleep.  Most people have restful sleep when taking daily Endorphinate® PR.  For continued sleep concerns, Endorphinate® CF can be taken before bedtime to promote restful sleep.
      • Side effects.  Endorphinate® PR is well tolerated by most individuals.  The only side effects reported (by less than 5% of respondents to our survey) were sleep-related. These concerns were resolved by using only CF in the evening.
      • Other drugs.  Endorphinate® has been used successfully with a wide variety of prescription and over-the-counter pain, anxiety, depression, sleep, addiction and  other medications. However, if you are taking other medications, please consult your health care practitioner before Endorphinate®.
      • Treatment of Disease. Endorphinate PR is not intended to diagnose, treat, cure, or prevent any disease.

Questions about Endorphinate®?  

Endorphinate® FAQ

What is an endorphin? Endorphins are endogenous opioid peptides that naturally exist within the human body. The body’s own natural endorphins as well as exogenous opioid drugs like Vicodin and Oxycontin provide a sense of calm, comfort, well being, and pleasure.

Why is it beneficial to increase endorphins?  Boosting endorphins naturally relieves emotional and physical distress and enhances our ability to handle stress and enjoy life.

Are there any problems with increasing endorphins? While endorphins normally inhibit distress and pain, if endorphin receptors are in an “excessive excitatory” rather than “normal inhibitory” mode, they paradoxically produce the opposite effect, increasing emotional and physical distress.

What causes a person’s endorphin system to be in “excessive excitatory mode”?  Prolonged stress, injury and drug and alcohol use can create “excessive excitatory mode” that cause endorphins to produce increased anxiety, anger, addiction, and pain.

Does Endorphinate® increase endorphins?  Yes. Endorphinate® increases endorphins by including ingredients such as guarana (which contains natural caffeine) and forskolin (“Endorphin Enhancers”) that increase endorphin levels.

Why is Endorphinate® better than caffeine?  Endorphinate’s patented formula includes n-acetyl-cysteine (NAC) and magnesium sulfate (“Receptor Switchers”), which switch endorphin receptors from excitatory signaling to inhibitory signaling.  By combining these Receptor Switchers with Endorphin Enhancers, Endorphinate® promotes increased inhibitory endorphin signaling.

Why does Endorphinate® help relieve anxiety and stress?  Anxiety can be produced by endorphins triggering excitatory signaling. Endorphinate® reverses this effect by switching receptors to the inhibitory mode and stimulating endorphin production.

Why does Endorphinate® help improve a depressed mood? Depression can be produced by depleted endorphins. Endorphinate® restores a positive mood by stimulating production of endorphins and related neurotransmitters.  By restoring healthy balance to the endorphin receptors, endorphins are more likely to trigger inhibitory signaling, thereby promoting calm, well being, and joy.

Why does Endorphinate® help relieve cravings?  Cravings for food, alcohol, and drugs are often produced by depleted endorphins and/or excessive excitatory endorphin receptor signaling.  With an imbalanced endorphin system, we yearn for substances that will enhance endorphins.  However, the result is more craving since excitatory signaling produces increased distress.  By restoring healthy balance to the endorphin system, pleasure and satisfaction are restored, and cravings are reduced.

Why does Endorphinate® provide a feeling of energy and mental clarity? By including Receptor Switchers in Endorphinate®, the caffeine, which is gradually released from the guarana in this unique, patented formulation, enhances energy and mental clarity without interference by the emotional and physical distress often triggered by taking caffeine (or guarana) alone.